The Workplace Health Research Network (WHRN), active from October 2014 through September 2016, sought to engage employers, employees and communities to advance knowledge and implement effective, comprehensive and integrated approaches to promote and protect worker health, safety and well-being. The types of approaches supported by the WHRN included research on environmental, policy, and systems interventions; and behavioral aspects contributing to individual employee health. A key focus was integrated, multi-component interventions that addressed multiple health risks and concerns in various worksite settings, sectors, and sizes. Its members conducted research across its six network centers, crossing academic affiliations and geographic boundaries. The WHRN was a thematic research network of the Prevention Research Centers (PRCs), which are the Centers for Disease Control and Prevention’s (CDC) flagship program for preventing and controlling chronic diseases.